Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke
نویسندگان
چکیده
منابع مشابه
Cattle encephalon glycoside and ignotin injection promoted synthesis of glial cell line-derived neurotrophic factor by astrocytes that protected against neuronal damage induced by AAPH
Cattle encephalon glycoside and ignotin injection offers neural protection after cerebral apoplexy clinically, but the exact mechanism of the protective effect is unclear. We performed primary culture of neurons and astrocytes and simulated ischemic brain damage using AAPH and discussed the action mechanism of cattle encephalon glycoside and ignotin injection. Results showed that cattle encepha...
متن کاملCattle encephalon glycoside and ignotin injection improves cognitive impairment in APPswe/PS1dE9 mice used as multitarget anti-Alzheimer’s drug candidates
BACKGROUND Cattle encephalon glycoside and ignotin injection (CEGI), a multitargeted neurotrophic drug, has been widely used in the treatment of central and peripheral nerve injuries, such as stroke, hypoxic ischemic encephalopathy, and diabetic neuropathy in the People's Republic of China. However, data regarding the effect of CEGI on Alzheimer's disease (AD) remain scarce. The present study a...
متن کاملFactors Affecting the Length of Hospital Stay in Patients with Ischemic Stroke Treated by Intravenous Thrombolysis
Background and purpose: Ischemic stroke is one of the most common neurological diseases that leads to disability in many cases. The aim of this study was to investigate the factors affecting the duration of hospitalization in patients with ischemic stroke undergoing thrombolytic therapy. Materials and methods: This retrospective descriptive-analytical study was performed in consecutive adult p...
متن کامل[Therapeutic time window in ischemic stroke].
近年,脳梗塞の治療では心筋梗塞の治療と同様に早 期診断・早期治療の重要性が叫ばれ,心筋梗塞が “Heart Attack”と呼ばれ可急的速やかに治療され一命 をとりとめるように,脳梗塞も“Brain Attack”と捉え 同様に速やかに治療を行い,後遺症を最小限にくいと めることの重要性が認識されつつある.脳虚血が発症 して脳血流が遮断されると脳組織は数時間で不可逆性 の変化をきたし壊死に陥って梗塞となる.ひとたび脳 梗塞に罹患すると片麻痺や言語障害などの神経症候, 記憶・記銘力の低下や情緒障害などの精神症状,さら にQOLの低下や痴呆症などの後遺症に苦しむことに なり社会的生命を失うことにもなる. 近年CT(computed tomography),MRI・A(magnetic resonance imaging・angiography),SPECT(single photon e...
متن کاملIschemic Stroke and Neuroprotection
Stroke is a major cause of morbidity and mortality in both developed and developing countries of the world. Greater understanding of the pathophysiology of neuronal damage in ischemic stroke has generated interest in neuroprotection as a management strategy. This paper aims to review the current concept and place of neuroprotection in ischemic stroke. An extensive search of all materials relate...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2021
ISSN: 1673-5374
DOI: 10.4103/1673-5374.290899